The INAIL research program promotes the safe and responsible development of nanotechnologies and new materials. The primary objective is to integrate safety and health principles from the very beginning of production, prioritizing the early elimination of risks in the design phase of new plants, processes, or products involving engineered nanomaterials (ENMs) and new and advanced materials (AdMa). The result is the identification and recommendation of safety and prevention measures to minimize workers' exposure and promote responsible nanotechnology-based innovation. The cooperation with IIT and production companies enhanced opportunities for exploitation of results. The workshop will address various aspects, including methodologies for risk assessment, exposure measurement and characterization of exposed workers, risk management, control strategies, and potential future developments and applications.