The success of modern drug and gene therapeutics depends not only on the development of innovative therapeutic agents but also on effective targeted delivery strategies capable of overcoming biological barriers. This session will explore advanced delivery approaches, including next-generation carriers for nucleic acids and small molecules, as well as tissue- and cell-targeted systems. The session will also highlight emerging concepts, including the contribution of mechanobiology and the influence of the cellular microenvironment on therapeutic delivery and performance, and the growing role of theranostic strategies that integrate diagnosis and therapy to enable more precise and personalized treatment. The session will provide an overview of emerging delivery technologies while encouraging interdisciplinary dialogue.