
Cervical cancer remains a significant global health burden, highlighting the need for more effective tools for early detection and tissue characterization. In this study, we propose a multimodal strategy that combines Raman spectroscopy, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM) to investigate the molecular and morphological features of cervical squamous cell carcinoma (SCC). Raman spectroscopy was used to analyze biochemical signatures across different tissue regions tumor, necrotic, stromal, and glandular within the 813–1668 cm-1 range, identifying distinct molecular profiles between malignant and healthy areas. Specific vibrational peaks associated with DNA, proteins, and lipids were examined to track molecular changes related to tumor progression. AFM enabled nanoscale mapping of surface morphology, revealing structural irregularities associated with malignancy, while SEM provided detailed imaging of cellular and extracellular architecture, enhancing the visualization of cancer-induced morphological alterations.


The leading scientific journal "ChemElectroChem" dedicates the cover of its n. 7 issue to a research entitled "X-Ray Microscopy: A Non-Destructive Multi-Scale Imaging to Study the Inner Workings of Batteries," carried out as part of the iENTRANCE project, at the new CNIS laboratories in Sapienza. Authors: Dr. Flavio Cognigni, Professor Mauro Pasquali, Dr. Francesca Anna Scaramuzzo, and Professor Marco Rossi of ICI-SBAI.