| ROOM 6 | ||||||
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WS.II NANOMATERIALS AND NANOTECHNOLOGIES ISSUES IN PUBLIC HEALTH 16 September |
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| Co-organised with: |
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| WORKSHOP COMMITTEE Francesco CUBADDA, Istituto Superiore di Sanità Valentina TIRELLI, Istituto Superiore di Sanità Beatrice BOCCA, Istituto Superiore di Sanità Annarica CALCABRINI, Istituto Superiore di Sanità |
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| 16 September | ||||||||
| 09:00 - 10:30 NAMs4NANO: unlocking the potential of NAMs in supporting the risk assessment of nanomaterials WS.II.1 - TT.I.A |
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Keeping pace with nanotechnology innovation and the steadily increasing number of new nanomaterials requires availability of robust and efficient human health risk assessment approaches for ensuring safety of novel nano-enabled products. New Approach Methodologies (NAMs) - comprising any technology, methodology or approach that can provide useful information to support chemical risk assessment without the use of animal tests (e.g. in silico, in chemico, in vitro) – have an enormous potential in this respect. NAMs4NANO, a research effort funded by the European Food Safety Authority (GP/EFSA/MESE/2022/01) subdivided in 3 lots with a 4-year duration, focuses on unlocking the potential of NAMs in supporting the risk assessment of nanomaterials applied in the food and feed sector. To reach this goal, 13 EU and non-EU research centres cooperate under the coordination of BfR, the German Federal Institute for Risk Assessment (Lot 1-2) and ISS, the Italian National Institute of Health (Lot 3). In Addition to the mandatory event registration on the official website at the LINK, partecipants are also invited to complete the participation form from this session at this other LINK.
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| WS.II.1.1 TT.I.A.1 |
Maria Chiara ASTUTO - CV EFSA The perspective of the European Food Safety Authority on NAMs in relation to food/feed nano-specific risk assessments |
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| WS.II.1.2 TT.I.A.2 |
Andrea HAASE - CV BfR A qualification system to accelerate development and regulatory implementation of NAMs |
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| WS.II.1.3 TT.I.A.3 |
Francesco CUBADDA - CV ISS The NAMs4NANO case studies: a broad NAM catalogue to address risk assessment challenges of real-world materials |
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| WS.II.1.4 TT.I.A.4 |
Francesca FERRARIS - CV ISS The physicochemical characterization and analytical platform underpinning NAMs4NANO |
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| 11:30 - 13:00 Exploring the Nanoscale: Flow Cytometry Methods and Applications for Nanoparticle Characterization WS.II.2 - TT.II.A |
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| Chairs: Valentina TIRELLI & Franco CARDONE, ISS | ||||||||
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Nano–flow cytometry is an advanced frontier of flow cytometry, enabling identification and characterization of nanoparticles (NP). In Addition to the mandatory event registration on the official website at the LINK, partecipants are also invited to complete the participation form from this session at this other LINK
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| WS.II.2.1 TT.II.A.1 |
Claudia Maria RADU - CV University of Padua Innovative Approaches to Nanoparticle Identification and Characterization by Flow Cytometry |
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| WS.II.2.2 TT.II.A.2 |
Stefano AMALFITANO - CV Water Research Institute, IRSA-CNR Flow cytometry for the analysis of micro/nanoparticles: current applications and environmental challenges |
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| WS.II.2.3 TT.II.A.3 |
Fabrizio MATTEI - CV ISS Immune-Derived Extracellular Vesicles for cancer therapy |
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| WS.II.2.4 TT.II.A.4 |
Aurelia RUGHETTI - CV Sapienza University of Rome EVS in tumor-immunity cross talk: exploring mechanisms and exploiting biomarkers |
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| 14:00 - 15:30 Micro‑ and nanoplastics: advancing knowledge from detection to mitigation WS.II.3 - TT.III.A |
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| Chairs: Cristina ANDREOLI - CV & Beatrice BOCCA - CV, ISS | ||||||||
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Micro- and nanoplastics are emerging global contaminants detected in air, water, soil, food, and consumer products, making human exposure unavoidable. Due to their small size, these particles may cross biological barriers and interact with cells and tissues, potentially inducing adverse biological effects that are still poorly understood. In response, the European Union has introduced regulatory measures and promoted the development of alternative materials, including bioplastics. This workshop aims to promote an integrated approach, aligned with the objectives of the BioPlast4Safe project, combining ecotoxicological studies, human biomonitoring of polymers, investigation of early-effect biomarkers, advanced analytical methodologies, and mitigation strategies. Together, these activities seek to improve exposure and risk assessment, reduce scientific uncertainties, and support evidence-based regulatory decisions for the safe management of these environmental contaminants. In Addition to the mandatory event registration on the official website at the LINK, partecipants are also invited to complete the participation form from this session at this other LINK
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| WS.II.3.1 TT.III.A.1 |
Giovanni LIBRALATO - CV University of Naples Federico II Micro- and Nanoplastics: ecotoxicological threats from ecosystems to human health |
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| WS.II.3.2 TT.III.A.2 |
Milica VELIMIROVIC FANFANI - CV Flemish Institute for Technological Research Advanced analytical strategies for reliable exposure assessment of micro- and nanoplastics |
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| WS.II.3.3 TT.III.A.3 |
Veruscka LESO - CV University of Naples Federico II Biomarkers of exposure and early biological responses to micro‑ and nanoplastics |
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| WS.II.3.4 TT.III.A.4 |
Mariacristina COCCA - CV Italian National Research Council Micro- and Nanoplastics: Advancing Knowledge from Detection to Mitigation |
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| 16:00 - 17:30 New drug delivery systems for biomedical applications WS.II.4 - TT.IV.A |
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| Chairs: Giuseppina BOZZUTO - CV & Marisa COLONE - CV, ISS | ||||||||
| Nanomedicine represents a key research field due to the growing use of nanoscale materials as carriers for the controlled transport and delivery of therapeutic or diagnostic agents to specific organ/tissue sites. New nanocarriers are continuously being designed and evaluated to overcome the problems associated with conventional chemotherapy (lack of specificity, low drug stability/bioavailability, systemic toxicity, drug-resistance occurrence). Numerous nanocarriers have improved the drug therapeutic efficacy in preclinical studies and, for some drugs, even in clinical trials. The workshop “New drug delivery systems for biomedical applications” will focus on the design and use of innovative systems for smart delivery of bioactive molecules and inorganic compounds with potential anticancer activity with the aim of modifying their distribution and reducing their toxicity thus improving future therapeutic efficacy. In Addition to the mandatory event registration on the official website at the LINK, partecipants are also invited to complete the participation form from this session at this other LINK |
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| WS.II.4.1 TT.IV.A.1 |
Annarita BILIA - CV Department of Chemistry Ugo Schiff, University of Florence Nanovectors: a smart approach to increase solubility, bioavailability and stability of drugs |
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| WS.II.4.2 TT.IV.A.2 |
Donato NICHIL - CV Sapienza University of Rome Preparation and characterization of polydatin–chitosan nanocapsules for enhanced drug delivery efficacy |
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| WS.II.4.3 TT.IV.A.3 |
Sofia MIGANI - CV ISS and University of Camerino Synthesis, structural studies and biological evaluation of copper(I) and copper(II) complexes supported by bis(pyrazol-1-yl)acetate ligand functionalized with amantadine for the treatment of glioblastoma |
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| WS.II.4.4 TT.IV.A.4 |
Miriam CAVIGLIA - CV ISS and University of Camerino Nanoparticle-assisted drug delivery of copper complexes as potential anticancer agents |
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